![]() ![]() Intuitively, loci that are associated with susceptibility will also be associated with severity as, to develop COVID-19, SARS-CoV-2 infection needs to first occur. We therefore developed a two-class Bayesian model for classifying loci based on the patterns of association across the two better-powered phenotypes (COVID-19 hospitalization and SARS-CoV-2 reported infection). This figure is reproduced from the original publication by the COVID-19 Host Genetics Initiative 2 with modifications reflecting the updated analysis from data freeze 6.Īcross the genome-wide significant loci, we observed clear patterns of association with the different phenotypes under study. The transparent loci were reported in the previous freeze (data release 5), and loci in bright blue were identified in the current freeze (data release 6). ![]() The asterisk (*) indicates SARS-CoV-2 reported infection and the plus symbol (+) indicates COVID-19 severity. V2G denotes the highest gene prioritized by OpenTargetGenetics’ V2G score. ![]() Genes in regions of linkage disequilibrium (LD), genes with coding variants and eGenes (fine-mapped cis-eQTL variant PIP > 0.1 in GTEx Lung) are annotated if in linkage disequilibrium with a COVID-19 lead variant ( r 2 > 0.6). b, The results of gene prioritization using different evidence measures of gene annotation. Horizontal lines denote genome-wide significant thresholds. Lead variants for the loci identified in this data release are annotated with their respective rs ID. Loci highlighted in green (bottom) are regions associated with SARS-CoV-2-reported infection. Loci highlighted in yellow (top) represent regions associated with the severity of COVID-19 manifestation. 3).Ī, The results of the genome-wide association study of hospitalized COVID-19 ( n = 25,027 cases and n = 2,836,272 control individuals) (top), and the results of reported SARS-CoV-2 infection ( n = 125,584 cases and n = 2,575,347 control individuals) (bottom). All of the other loci showed the expected increase in statistical significance (Supplementary Fig. We compared the effects of these loci between the previous 2 and current analysis and found that only one locus did not replicate (rs72711165). We found a total of 23 genome-wide significant loci ( P < 5 × 10 −8) of which 20 loci remain significant after correction for multiple testing ( P < 1.67 × 10 −8) to account for the number of phenotypes examined (Fig. Most studies have reported results before the roll out of the COVID-19 vaccination campaign. An overview of the study design is provided in Supplementary Fig. 1 and Supplementary Table 1) for three COVID-19-related phenotypes: (1) individuals critically ill with COVID-19 on the basis of requiring respiratory support in hospital or who died as a consequence of the disease (9,376 cases, of which 3,197 are new in this data release, and 1,776,645 control individuals) (2) individuals with moderate or severe COVID-19 defined as those hospitalized due to symptoms associated with the infection (25,027 cases, 11,386 new and 2,836,272 control individuals) and (3) all cases with reported SARS-CoV-2 infection regardless of symptoms (125,584 cases, 76,022 new and 2,575,347 control individuals). Elizabeth Hammill and William Hammill Jr.Here we present meta-analyses bringing together 60 studies from 25 countries (Fig.Family Life Christian Fellowship Church.Adam and Heather Soloff Foundation Fund.Soroptimist International of Cumberland County, Inc.Alexander Deschaine and Kathryn Deschaine.Vincent De Paul Society Holy Angels Conference Professional Pain Management Associates.Ragone, Lacatena, Fairchild, & Beppel, PC.Parkside Business & Community in Partnership, Inc.Community Planning and Advocacy Council.New Jersey Coalition to End Domestic Violence.The Larry and Mary Kent Charitable Fund.Camden Coalition of Healthcare Providers.Caring Partners of Morris & Sussex County.United Way of Greater Philadelphia and Southern New Jersey.Cooper University Healthcare and Foundation.Camden Community Partnership (formerly Coopers Ferry).The Leadership Circle includes donors making an annual gift commitment of $20,000 or more. Thank you for being an important partner in this important work. Contributions from individual and community partners play a critical role in improving the lives of those most in need. ![]()
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